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How mutation affects heart health
Researchers studied heart muscle cells derived from pluripotent stem cells to find out why a genetic mutation common in East Asians leads to an increased risk of heart disease.
Flu revs up immune response in pregnancy
Immune cells from pregnant women are strongly activated by influenza — a surprising finding that may explain the increased risk of flu complications in pregnancy, a new study finds.
Protein may stop spread of cancer
An experimental therapy stopped the metastasis of breast and ovarian cancers in lab mice, pointing toward a potentially safe and effective alternative to chemotherapy.
Vision & Leadership
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A Legacy of Innovation
First synthesis of biologically active DNA in test tube
Nobel laureate Arthur Kornberg creates a strand of biologically active DNA, paving the way for studies of genetics.
First adult human heart transplant in the United States
Norman Shumway successfully transplants a heart into 54-year-old steelworker Mike Kasperak, who survives for 14 days.
First expression of a foreign gene implanted in bacteria by recombinant DNA methods
Geneticist Stanely Cohen transfers a foreign gene into bacterial cells, which then express the gene.
First successful human combined heart/lung transplant in the world (fourth attempted worldwide)
Mary Gohlke receives the world's first combined heart and lung transplant in a landmark operation led by surgeon Bruce Reitz.
Isolation of pure hematopoietic stem cells from mice
Pathologist Irving Weissman isolates a rare mouse cell, known as the hematopoetic stem cell, which gives rise to all the cells of the blood and immune systems.
First use of gene expression profiling to predict cancer outcomes
Application and expansion of optogenetics, a technique to control brain cell activity with light
Bioengineer Karl Deisseroth and his team develop a technique known as optogenetics that allows them to genetically alter brain cell activity in mice with light.